Adjacent cells share ions, second messengers and small metabotes through intercellular
channels which are present in gap junctions. This type of intercellular communication …

Antitumor suicide gene therapy is one of the emerging strategies against cancer. It consists
of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a …

In gene therapy to treat cancer, typically only a fraction of the tumor cells can be successfully
transfected with a gene. However, in the case of brain tumor therapy with the thymidine …

Many lines of evidence indicate that connexin genes expressing gap junction (GJ) proteins
inhibit tumor cell proliferation. However, the precise molecular mechanisms remain unclear …

Since the demonstration of the multistage nature of carcinogenesis in experimental work on
mouse skin carcinogenesis (and subsequently on various other organ systems in other …

We have characterized the function of connexin (Cx) 32 gene mutations found in X-linked
dominant Charcot-Marie-Tooth disease with respect to their ability to form functional gap …

Methods and compositions are provided for controlling cell distribution within an implantable
bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes …

A tumor is made up of a heterogeneous collection of cell types, all competing on a fitness
landscape mediated by microenvironmental conditions that dictate their interactions. Despite …

The effects of three tumor promoters on gap‐junction permeability; connexin 43 and 26
mRNA levels, protein levels, and phosphorylation; and the numbers of gap‐junctional …

The sequence of events involved in maintenance of homeostasis must encompass
mechanisms within single cells as well as interactions between cells within a population. To …