Oxidative stress and hypertension

KK Griendling, LL Camargo, FJ Rios… - Circulation …, 2021 - Am Heart Assoc
A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

P Lee, NS Chandel, MC Simon - Nature reviews Molecular cell biology, 2020 - nature.com
Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

Detection of immunogenic cell death and its relevance for cancer therapy

J Fucikova, O Kepp, L Kasikova, G Petroni… - Cell death & …, 2020 - nature.com
Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically
relevant tumor-targeting immune responses, which critically rely on the antigenicity of …

Autophagy in liver diseases: a review

H Qian, X Chao, J Williams, S Fulte, T Li, L Yang… - Molecular aspects of …, 2021 - Elsevier
The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

In response to precision medicine: Current subcellular targeting strategies for cancer therapy

Z Li, J Zou, X Chen - Advanced Materials, 2023 - Wiley Online Library
Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

The C/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection

H Hu, M Tian, C Ding, S Yu - Frontiers in immunology, 2019 - frontiersin.org
Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal
environment. Apoptosis is an initiative cell death process that is controlled by genes and is …

Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways

CWG Redman, AC Staff, JM Roberts - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia evolves in 2 stages: a placental problem that generates signals to the mother
to cause a range of responses that comprise the second stage (preeclampsia syndrome) …

Healthy effects of plant polyphenols: molecular mechanisms

M Leri, M Scuto, ML Ontario, V Calabrese… - International journal of …, 2020 - mdpi.com
The increasing extension in life expectancy of human beings in developed countries is
accompanied by a progressively greater rate of degenerative diseases associated with …

[HTML][HTML] A guide to understanding endoplasmic reticulum stress in metabolic disorders

IL Lemmer, N Willemsen, N Hilal, A Bartelt - Molecular metabolism, 2021 - Elsevier
Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …