In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …

Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …

DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …

Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …

DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …

Plasma cell-free DNA (cfDNA) are small molecules generated through a non-random
fragmentation procedure. Despite commendable translational values in cancer liquid biopsy …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …