CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …

Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Technological advances allowing high throughput analyses across numerous cancer
tissues have allowed much progress in understanding complex cellular signaling. In the …

Abstract Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are
essential for normal lymphoid development. In their absence, severe combined …

The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in
treatment of various human cancers. CK2 overexpression has been demonstrated in …