Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-
functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic disorder and constitutes
approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients …

Ikaros (IKZF1) is a tumor suppressor that binds DNA and regulates expression of its target
genes. The mechanism of Ikaros activity as a tumor suppressor and the regulation of Ikaros …

Abstract MicroRNA-21 (miR-21) was recognized as a key figure in the intricate web of tumor
biology, with a prominent role in regulating the PTEN tumor suppressor gene and the …

Phosphorylation regulates the conformation, stability, homo-and heterotypic protein
interactions, localization, and activity of the tumor suppressor PTEN. From a simple picture …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

A multitude of proteins are aberrantly expressed in cancer cells, including the oncogenic
serine-threonine kinase CK2. In a previous report, we found increases in CK2 transcript …

PTEN has been studied in several tumor models as a tumor suppressor. In this study, we
explored the role of PTEN in the inhibition state of polarized M2 subtype of macrophage in …

The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates
phosphatidylinositol 3-kinase (PI3K)-AKT signaling and is often inactivated by mutations …