CK2 and AKT display a high degree of cross-regulation of their respective functions, both
directly, through physical interaction and phosphorylation, and indirectly, through an intense …

The incidence of cancer is increasing worldwide, but the biochemical mechanisms for the
occurrence of cancer is not fully understood, and there is no cure for advanced tumors …

The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved
serine/threonine kinase overexpressed in various human carcinomas and its high …

PURPOSE: We investigated the antitumor effect of the casein kinase II (CK2) inhibitor CX-
4945 on cholangiocarcinoma (CCA). METHODS: We assessed the effect of CX-4945 alone …

Background: Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a
promising therapeutic target in cancer. Recent studies have revealed an important role for …

The reprogramming of cellular metabolism is frequently linked to tumorigenesis. Glucose,
fatty acids, and amino acids are the specific substrates involved in how an organism …

Introduction: A multitude of cellular and physiological functions have been attributed to the
biological activity of PTEN (Phosphatase and tensin homolog) such as inhibiting …

Impaired function of the Ikaros (IKZF1) protein is associated with the development of high-
risk B-cell precursor acute lymphoblastic leukemia (B-ALL). The mechanisms of Ikaros tumor …

Despite considerable progress in treatment protocols, B‐lineage acute lymphoblastic
leukemia (B‐ALL) displays a poor prognosis in about 15–20% of pediatric cases and about …

High-risk B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive disease, often
characterized by resistance to chemotherapy. A frequent feature of high-risk B-ALL is loss of …