Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …

HIV-1/AIDS remains a global public health problem. The world health organization (WHO)
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …

The HIV latent reservoir represents the major challenge to cure development. Residing in
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …

The availability of combined antiretroviral therapy (cART) has revolutionized the course of
HIV infection, suppressing HIV viremia, restoring the immune system, and improving the …

Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …

Latent HIV reservoir is the main obstacle that prevents a cure for HIV-1 (HIV). While
antiretroviral therapy is effective in controlling viral replication, it cannot eliminate latent HIV …

Eradication of latent human immunodeficiency virus (HIV) infection is a global health
challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick …

The HIV-1 latent reservoir is established early after infection, persists during antiretroviral
therapy, and is the source of viral rebound after treatment interruption. An HIV cure requires …

Antiretroviral therapy effectively controls human immunodeficiency virus (HIV) infection.
However, a reservoir of latently infected cells persists under suppressive therapy …

Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is
not curative. The major barrier to finding a definitive cure for HIV is our inability to identify …