Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain
development. The recent finding of the microbiota–gut–brain axis indicates the bidirectional …

Trillions of microbes live within our bodies in a deep symbiotic relationship. Microbial
populations vary across body sites, driven by differences in the environment, immunological …

Variations in oxygen levels play key roles in numerous physiological and pathological
processes, but are often not properly controlled in in vitro models, introducing a significant …

The gut microbiota, which represent a community of different microorganisms in the human
intestinal tract, are crucial to preserving human health by participating in various …

Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is typically
initiated by inactivation of the von Hippel Lindau (VHL) gene, which results in the constitutive …

Abstract Currently available European Alpine Altitude Climate Treatment (AACT) programs
combine the physical characteristics of altitude with the avoidance of environmental triggers …

Epithelial cells that line tissues such as the intestine serve as the primary barrier to the
outside world. Epithelia provide selective permeability in the presence of a large …

Background Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) have
improved the treatment of renal anemia, especially in patients resistant to erythropoiesis …

Background The epithelium in the colonic mucosa is implicated in the pathophysiology of
various diseases, including inflammatory bowel diseases and colorectal cancer. Intestinal …

Hypoxia-inducible factor-1α (HIF-1α), a central player in maintaining gut-microbiota
homeostasis, plays a pivotal role in inducing adaptive mechanisms to hypoxia and is …