Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …

How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …

Collective cell migration underlies morphogenesis, wound healing and cancer invasion,.
Most directed migration in vivo has been attributed to chemotaxis, whereby cells follow a …

Natural tissues and organs exhibit an array of spatial gradients, from the polarized neural
tube during embryonic development to the osteochondral interface present at articulating …

The directed migration of cellular clusters enables morphogenesis, wound healing and
collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular …

Although understanding how soluble cues direct cellular processes revolutionised the study
of cell biology in the second half of the 20th century, over the last two decades, new insights …

Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness,
has been proposed as a mechanism driving directed migration. Despite the lack of evidence …

Directed cell migration is essential for cells to efficiently migrate in physiological and
pathological processes. While migrating in their native environment, cells interact with …

Spatiotemporal changes in viscoelasticity are a key component of the morphogenesis of
living systems. Experimental and theoretical findings suggest that cellular-and tissue-scale …