Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …
oxidant molecules with vastly different properties and biological functions that range from …
The spectrum of inflammatory responses
R Medzhitov - Science, 2021 - science.org
Inflammation is an integral part of animal biology. It provides critical protection from adverse
environmental factors by enforcing the defense of homeostasis and the functional and …
environmental factors by enforcing the defense of homeostasis and the functional and …
Environmental factors influencing COVID-19 incidence and severity
Emerging evidence supports a link between environmental factors—including air pollution
and chemical exposures, climate, and the built environment—and severe acute respiratory …
and chemical exposures, climate, and the built environment—and severe acute respiratory …
Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
[HTML][HTML] Gene–environment interactions and their impact on human health
SJ Virolainen, A VonHandorf, KCMF Viel… - Genes & …, 2023 - nature.com
The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …
genetic and environmental factors contribute to a given disease or phenotype in a non …
[HTML][HTML] Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis
Z Lv, J Han, J Li, H Guo, Y Fei, Z Sun, J Dong… - …, 2022 - thelancet.com
Background Osteoarthritis (OA) is the most common degenerative joint disease primarily
characterized by cartilage destruction. The aim of this study was to investigate the role …
characterized by cartilage destruction. The aim of this study was to investigate the role …
Multiomics to elucidate inflammatory bowel disease risk factors and pathways
M Agrawal, KH Allin, F Petralia, JF Colombel… - Nature Reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …
complex pathophysiology involving genetic, environmental, microbiome, immunological and …
The accelerated aging phenotype: the role of race and social determinants of health on aging
The pursuit to discover the fundamental biology and mechanisms of aging within the context
of the physical and social environment is critical to designing interventions to prevent and …
of the physical and social environment is critical to designing interventions to prevent and …
[HTML][HTML] A precision environmental health approach to prevention of human disease
Human health is determined by the interaction of our environment with the genome,
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …
Defining the scope of exposome studies and research needs from a multidisciplinary perspective
P Zhang, C Carlsten, R Chaleckis… - … science & technology …, 2021 - ACS Publications
The concept of the exposome was introduced over 15 years ago to reflect the important role
that the environment exerts on health and disease. While originally viewed as a call-to-arms …
that the environment exerts on health and disease. While originally viewed as a call-to-arms …