Mechanisms of age‐related macular degeneration and therapeutic opportunities
M van Lookeren Campagne, J LeCouter… - The Journal of …, 2014 - Wiley Online Library
As the age of the population increases in many nations, age‐related degenerative diseases
pose significant socioeconomic challenges. One of the key degenerative diseases that …
pose significant socioeconomic challenges. One of the key degenerative diseases that …
Geographic atrophy: clinical features and potential therapeutic approaches
FG Holz, EC Strauss, S Schmitz-Valckenberg… - Ophthalmology, 2014 - Elsevier
In contrast to wet age-related macular degeneration (AMD), where loss of vision is typically
acute and treatment leads to a relatively rapid reduction in retinal fluid and subsequent …
acute and treatment leads to a relatively rapid reduction in retinal fluid and subsequent …
[HTML][HTML] Giant five-photon absorption from multidimensional core-shell halide perovskite colloidal nanocrystals
Multiphoton absorption processes enable many technologically important applications, such
as in vivo imaging, photodynamic therapy and optical limiting, and so on. Specifically, higher …
as in vivo imaging, photodynamic therapy and optical limiting, and so on. Specifically, higher …
[HTML][HTML] Chemistry of the retinoid (visual) cycle
As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …
Nonlinear photonics using low‐dimensional metal‐halide perovskites: recent advances and future challenges
W Chen, F Zhang, C Wang, M Jia, X Zhao… - Advanced …, 2021 - Wiley Online Library
Low‐dimensional metal‐halide perovskites have exhibited significantly superior nonlinear
optical properties compared to traditional semiconductor counterparts, thanks to their …
optical properties compared to traditional semiconductor counterparts, thanks to their …
[HTML][HTML] Chemistry and biology of vision
K Palczewski - Journal of Biological Chemistry, 2012 - ASBMB
Visual perception in humans occurs through absorption of electromagnetic radiation from
400 to 780 nm by photoreceptors in the retina. A photon of visible light carries a sufficient …
400 to 780 nm by photoreceptors in the retina. A photon of visible light carries a sufficient …
[HTML][HTML] Recent developments in the treatment of age-related macular degeneration
FG Holz, S Schmitz-Valckenberg… - The Journal of …, 2014 - Am Soc Clin Investig
Age-related macular degeneration (AMD) is a common cause of visual loss in the elderly,
with increasing prevalence due to increasing life expectancy. While the introduction of anti …
with increasing prevalence due to increasing life expectancy. While the introduction of anti …
[HTML][HTML] Genome editing in the treatment of ocular diseases
Genome-editing technologies have ushered in a new era in gene therapy, providing novel
therapeutic strategies for a wide range of diseases, including both genetic and nongenetic …
therapeutic strategies for a wide range of diseases, including both genetic and nongenetic …
[HTML][HTML] Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration
Y Chen, K Okano, T Maeda, V Chauhan… - Journal of Biological …, 2012 - ASBMB
Compromised clearance of all-trans-retinal (atRAL), a component of the retinoid cycle,
increases the susceptibility of mouse retina to acute light-induced photoreceptor …
increases the susceptibility of mouse retina to acute light-induced photoreceptor …
[HTML][HTML] In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope
J Boguslawski, G Palczewska… - The Journal of …, 2022 - Am Soc Clin Investig
Background Noninvasive assessment of metabolic processes that sustain regeneration of
human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics …
human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics …