Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Purpose Current reports on acute kidney injury (AKI) in the intensive care unit (ICU) show
wide variation in occurrence rate and are limited by study biases such as use of incomplete …

Background Traditionally, renal function in critically ill patients has been assessed to identify
renal dysfunction, and dose adjustment is generally accepted in such a context …

The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

Patients with cirrhosis, particularly those with decompensated cirrhosis, are at increased risk
of bacterial infections that may further precipitate other liver decompensations including …

Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …

Background The optimal dosing of antibiotics in critically ill patients receiving renal
replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT …

Purpose There is variability in the pharmacokinetics (PK) of antibiotics (AB) in critically ill
patients. Therapeutic drug monitoring (TDM) could overcome this variability and increase PK …

Purpose Risk factors for β-lactam antibiotic underdosing in critically ill patients have not
been described in large-scale studies. The objective of this study was to describe …