mTORC1 and SGLT2 Inhibitors—A Therapeutic Perspective for Diabetic Cardiomyopathy

S Saha, X Fang, CD Green, A Das - International Journal of Molecular …, 2023 - mdpi.com
Diabetic cardiomyopathy is a critical diabetes-mediated co-morbidity characterized by
cardiac dysfunction and heart failure, without predisposing hypertensive or atherosclerotic …

Immune modulation as a key mechanism for the protective effects of remote ischemic conditioning after stroke

S Abbasi-Habashi, GC Jickling, IR Winship - Frontiers in Neurology, 2021 - frontiersin.org
Remote ischemic conditioning (RIC), which involves a series of short cycles of ischemia in
an organ remote to the brain (typically the limbs), has been shown to protect the ischemic …

View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences

G Froldi - Pharmaceuticals, 2024 - mdpi.com
Metformin is a synthetic biguanide used as an antidiabetic drug in type 2 diabetes mellitus,
achieved by studying the bioactive metabolites of Galega officinalis L. It is also used off-label …

The influence of SLC22A3 rs543159 and rs1317652 genetic variants on metformin therapeutic efficacy in newly diagnosed patients with type 2 diabetes mellitus: 25 …

R Taheri, F Kazerouni, R Mirfakhraei, S Kalbasi… - Gene, 2022 - Elsevier
Background and aims Among anti-diabetic medications, metformin has been proven to be
the preferred initial pharmacologic agent for type 2 diabetes mellitus (T2DM) treatment …

Gallic acid improves the metformin effects on diabetic kidney disease in mice

Y Hong, J Wang, W Sun, L Zhang, X Xu, K Zhang - Renal Failure, 2023 - Taylor & Francis
Objectives Metformin is an antidiabetic agent that is used as the first-line treatment of type 2
diabetes mellitus. Gallic acid is a type of phenolic acid that has been shown to be a potential …

Recent progress in the diagnosis and management of type 2 diabetes mellitus in the era of COVID-19 and single cell multi-omics technologies

K Kupai, T Várkonyi, S Török, V Gáti, Z Czimmerer… - Life, 2022 - mdpi.com
Type 2 diabetes mellitus (T2DM) is one of the world's leading causes of death and life-
threatening conditions. Therefore, we review the complex vicious circle of causes …

Pharmaceutical drug metformin and MCL1 inhibitor S63845 exhibit anticancer activity in myeloid leukemia cells via redox remodeling

G Valiulienė, A Vitkevičienė, G Skliutė, V Borutinskaitė… - Molecules, 2021 - mdpi.com
Metabolic landscape and sensitivity to apoptosis induction play a crucial role in acute
myeloid leukemia (AML) resistance. Therefore, we investigated the effect of metformin, a …

[HTML][HTML] Extracts from Phyllanthus emblica L stem barks ameliorate blood glucose level and pancreatic and hepatic injuries in streptozotocin-induced diabetic rats

Q Quranayati, M Iqhrammullah, N Saidi… - Arabian Journal of …, 2023 - Elsevier
Phyllanthus emblica L is a promising medicinal plant for antidiabetic therapy but current
research has not explored its stem bark potential as an antidiabetic agent despite the fact …

Effect of metformin (vs. placebo or sulfonylurea) on all-cause and cardiovascular mortality and incident cardiovascular events in patients with diabetes: an umbrella …

M Bahardoust, S Mousavi, M Yariali… - Journal of Diabetes & …, 2024 - Springer
Purpose The current umbrella review aimed to evaluate the effect of metformin on all-cause
mortality (ACM), cardiovascular mortality, and cardiovascular disease (CVD) incidence in …

Metformin and risk of malignant brain tumors in patients with type 2 diabetes mellitus

CH Tseng - Biomolecules, 2021 - mdpi.com
The risk of malignant brain tumors associated with metformin use has rarely been
investigated in humans. This retrospective cohort study investigated such an association …