The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …

Rare diseases affect over 400 million people worldwide and less than 5% of rare diseases
have an approved treatment. Fortunately, the number of underlying disease etiologies is far …

Programmable base editors and prime editors offer the potential for highly efficient and
precise genome manipulation. However, in order to safely apply these editors in clinical …

Advancements in CRISPR technology, particularly the development of base editors,
revolutionize genetic variant research. When combined with model organisms like zebrafish …

Clustered regularly interspaced short palindromic repeat (CRISPR) has been gaining much
attention in the modern medical field and has been widely used for the diagnosis and …

Hematopoietic stem cell transplant has for years provided lifesaving options for many
hematologic malignancies, and, by establishing the technological and clinical path for …

Enzymes of the apolipoprotein B mRNA editing catalytic polypeptide like (APOBEC) family
are cytosine deaminases that convert cytosine to uracil in DNA and RNA. Among these …

Base editors (BEs) consist of partially active Cas9 homologs fused to nucleobase-converting
DNA deaminases along with certain accessory proteins. The effectiveness of BE tools …

Genome editing holds great promise for the molecular breeding of plants, yet its application
is hindered by the shortage of simple and effective means of delivering genome editing …

DNA glycosylases are enzymes that hydrolyze the N-glycosidic bond of damaged
nucleotides, initiating the process of base excision DNA repair. There are at least eight …