APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
JL McCann, A Cristini, EK Law, SY Lee, M Tellier… - Nature Genetics, 2023 - nature.com
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
Targeting shared molecular etiologies to accelerate drug development for rare diseases
G Zanello, M Garrido‐Estepa, A Crespo… - EMBO molecular …, 2023 - embopress.org
Rare diseases affect over 400 million people worldwide and less than 5% of rare diseases
have an approved treatment. Fortunately, the number of underlying disease etiologies is far …
have an approved treatment. Fortunately, the number of underlying disease etiologies is far …
Characterizing off-target effects of genome editors
Programmable base editors and prime editors offer the potential for highly efficient and
precise genome manipulation. However, in order to safely apply these editors in clinical …
precise genome manipulation. However, in order to safely apply these editors in clinical …
ABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish
Advancements in CRISPR technology, particularly the development of base editors,
revolutionize genetic variant research. When combined with model organisms like zebrafish …
revolutionize genetic variant research. When combined with model organisms like zebrafish …
The application of CRISPR-Cas in disease diagnosis and treatment
Z Wang, Y Liu, F Zhou, Y Wang, X Zhou - Science China Chemistry, 2023 - Springer
Clustered regularly interspaced short palindromic repeat (CRISPR) has been gaining much
attention in the modern medical field and has been widely used for the diagnosis and …
attention in the modern medical field and has been widely used for the diagnosis and …
Serving up whatever you wish: CRISPR-base editing generates novel cancer-restricted antigens for immunotherapy
UE Burkhardt, EF Fritsch - Genes & Immunity, 2023 - nature.com
Hematopoietic stem cell transplant has for years provided lifesaving options for many
hematologic malignancies, and, by establishing the technological and clinical path for …
hematologic malignancies, and, by establishing the technological and clinical path for …
Regulation, Functional Impact, and Therapeutic Targeting of APOBEC3A in Cancer
Enzymes of the apolipoprotein B mRNA editing catalytic polypeptide like (APOBEC) family
are cytosine deaminases that convert cytosine to uracil in DNA and RNA. Among these …
are cytosine deaminases that convert cytosine to uracil in DNA and RNA. Among these …
Cas9 variants expand the targeting scope of base editing systems in bacteria
RM Shelake, JY Kim - The Nucleus, 2024 - Springer
Base editors (BEs) consist of partially active Cas9 homologs fused to nucleobase-converting
DNA deaminases along with certain accessory proteins. The effectiveness of BE tools …
DNA deaminases along with certain accessory proteins. The effectiveness of BE tools …
Exploiting viral vectors to deliver genome editing reagents in plants
Y Shen, T Ye, Z Li, TH Kimutai, H Song, X Dong, J Wan - aBIOTECH, 2024 - Springer
Genome editing holds great promise for the molecular breeding of plants, yet its application
is hindered by the shortage of simple and effective means of delivering genome editing …
is hindered by the shortage of simple and effective means of delivering genome editing …
Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes
AV Endutkin, DO Zharkov - Moscow University Chemistry Bulletin, 2024 - Springer
DNA glycosylases are enzymes that hydrolyze the N-glycosidic bond of damaged
nucleotides, initiating the process of base excision DNA repair. There are at least eight …
nucleotides, initiating the process of base excision DNA repair. There are at least eight …