High-fat diet-induced obesity in animal models

N Hariri, L Thibault - Nutrition research reviews, 2010 - cambridge.org
Epidemiological studies have shown a positive relationship between dietary fat intake and
obesity. Since rats and mice show a similar relationship, they are considered an appropriate …

[HTML][HTML] Modeling diet-induced obesity with obesity-prone rats: implications for studies in females

ED Giles, MR Jackman, PS MacLean - Frontiers in Nutrition, 2016 - frontiersin.org
Obesity is a worldwide epidemic, and the comorbidities associated with obesity are
numerous. Over the last two decades, we and others have employed an outbred rat model to …

Orexin gene expression is increased during states of hypertriglyceridemia

KE Wortley, GQ Chang, Z Davydova… - American Journal of …, 2003 - journals.physiology.org
Previous reports implicate the orexins in eating and body weight regulation. This study
investigated possible functional relationships between hypothalamic orexins and circulating …

Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasia

MR Jackman, A Steig, JA Higgins… - American Journal …, 2008 - journals.physiology.org
A dual-tracer approach (dietary 14C-palmitate and intraperitoneal 3H-H2O) was used to
assess the trafficking of dietary fat and net retention of carbon in triglyceride depots during …

[HTML][HTML] Classification of different degrees of adiposity in sedentary rats

AS Leopoldo, AP Lima-Leopoldo… - Brazilian Journal of …, 2016 - SciELO Brasil
In experimental studies, several parameters, such as body weight, body mass index,
adiposity index, and dual-energy X-ray absorptiometry, have commonly been used to …

[HTML][HTML] Exercise decreases lipogenic gene expression in adipose tissue and alters adipocyte cellularity during weight regain after weight loss

ED Giles, AJ Steig, MR Jackman, JA Higgins… - Frontiers in …, 2016 - frontiersin.org
Exercise is a potent strategy to facilitate long-term weight maintenance. In addition to
increasing energy expenditure and reducing appetite, exercise also favors the oxidation of …

Model for predicting and phenotyping at normal weight the long-term propensity for obesity in Sprague–Dawley rats

JT Dourmashkin, GQ Chang, JO Hill, EC Gayles… - Physiology & …, 2006 - Elsevier
Tests were conducted to determine whether weight gain or nutrient intake measures during
the first week of exposure to a macronutrient diet can accurately predict an animal's long …

Impact of high‐fat diet and obesity on energy balance and fuel utilization during the metabolic challenge of lactation

JL Wahlig, ES Bales, MR Jackman, GC Johnson… - …, 2012 - Wiley Online Library
The effects of obesity and a high‐fat (HF) diet on whole body and tissue‐specific metabolism
of lactating dams and their offspring were examined in C57/B6 mice. Female mice were fed …

Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men

MT Timlin, BR Barrows, EJ Parks - Diabetes, 2005 - Am Diabetes Assoc
Sources of fatty acids flowing to the liver may be used for triacylglycerol (TAG) synthesis. Our
objective was to quantify contributions of nonesterified fatty acids (NEFAs), de novo …

[HTML][HTML] Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis

JL Saben, ES Bales, MR Jackman, D Orlicky… - PLoS …, 2014 - journals.plos.org
Maternal metabolic and nutrient trafficking adaptations to lactation differ among lean and
obese mice fed a high fat (HF) diet. Obesity is thought to impair milk lipid production, in part …