Background and aims Proprotein convertase subtilisin/kexin 9 (PCSK9) has emerged as a
popular target in the development of new cholesterol-lowering drugs and therapeutic …

Reactive carbonyl compounds (RCCs) formed during lipid peroxidation and sugar
glycoxidation, namely Advanced lipid peroxidation end products (ALEs) and Advanced …

Rationale: Activated nuclear factor (NF)-κB signaling in the vascular endothelium promotes
the initiation and progression of atherosclerosis. Targeting endothelial NF-κB may provide a …

Macrophages are cells of the innate immune system and represent an important component
of the first-line defense against pathogens and tumor cells. Here, their diverse functions in …

Proprotein convertase subtilisin/kexin Type 9 (PCSK9) is now identified as an important and
major player in hypercholesterolaemia and atherosclerosis pathophysiology. PCSK9 …

Individuals with type 2 diabetes mellitus have increased cardiovascular disease risk
compared with those without diabetes. Treatment of the residual risk, other than blood …

Aging is associated with impaired vascular endothelial function, as indicated in part by
reduced endothelium-dependent dilation (EDD). Decreased EDD with aging is thought to be …

Nuclear factor (NF)-κB has an important role in immunity and inappropriate NF-κB activity
has been linked with many autoimmune and inflammatory diseases. Multiple mechanisms …

Obstructive sleep apnea (OSA) is independently associated with death from cardiovascular
diseases, including myocardial infarction and stroke. Myocardial infarction and stroke are …

Antisense Noncoding RNA in the INK4 Locus (ANRIL) is the prime candidate gene at
Chr9p21, the well-defined genetic risk locus associated with multiple human diseases …