The discovery of the glycosphingolipids is generally attributed to Johan LW Thudichum, who
in 1884 published on the chemical composition of the brain. In his studies he isolated …

Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated
forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial …

Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct
organisms. However, the identification of species-specific fixed genetic variants requires the …

Mucosal epithelium functions not only as a physical barrier, but also as a regulator of innate
and adaptive immune responses against foreign substances and microorganisms. In …

The aim of this study was to examine the expression of G protein-coupled receptor (GPR) 35
in human invariant natural killer T (iNKT) cells and to determine the functional effects …

Lysosomal storage diseases are inherited monogenic disorders in which lysosome function
is compromised. Although individually very rare, they occur at a collective frequency of …

The broad complex, tramtrack, bric-a-brac–zinc finger (BTB-ZF) transcription factor
promyelocytic leukemia zinc finger (PLZF) is required for development of the characteristic …

Release of NAD+ during preparation of murine lymphocytes causes enzymatic ADP-
ribosylation of cell-surface proteins on T cells, catalyzed by toxin-related ecto-ADP …

Through the analysis of CD1d expression by flow cytometry and qRT-PCR we showed lower
CD1d molecule and CD1d mRNA expression in B cells of CLL patients than of healthy …

A highly efficient synthesis of the biologically important fluorescent probe dansyl α-GalCer is
presented. Key in our strategy is the incorporation of the fluorescent dansyl group at an early …