SLC7A11 is a cell transmembrane protein composing the light chain of system xc−,
transporting extracellular cystine into cells for cysteine production and GSH biosynthesis …

Cancer metabolic alterations have been emphasized to protect cancer cells from cell death.
The metabolic reprogramming toward a mesenchymal state makes cancer cells resistant to …

Abstract Background/Aim Colorectal cancer (CRC), is characterized by aberrant microRNA
(miRNA) expression during their development and progression. Recently, miR-509–5p's …

Reprogramming of lipid metabolism, which modulates energy utilization and cell signaling,
maintains cell survival and promotes cancer metastasis in cancer cells. Ferroptosis is a type …

Cancer cells develop multiple strategies to evade T cell-mediated killing. On one hand,
cancer cells may preferentially rely on certain amino acids for rapid growth and metastasis …

Background Malignant transformation from hepatic fibrosis to carcinogenesis may be a
therapeutic target for hepatocellular carcinoma (HCC). The aim of this study was to evaluate …

Ferroptosis is a type of controlled cell death caused by lipid peroxidation, which results in
the rupture of the cell membrane. ferroptosis has been repeatedly demonstrated over the …

The growth state of tumor cells is strictly affected by the specific abnormal redox status of the
tumor microenvironment (TME). Moreover, redox reactions at the biological level are also …

Dimethylarsinic acid (DMA) is a major metabolite in the urine of humans and rats exposed to
inorganic arsenicals, and is reported to induce rat bladder carcinogenesis. In the present …

The non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc-is
composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the …