Exploiting the critical perioperative period to improve long-term cancer outcomes

M Horowitz, E Neeman, E Sharon… - Nature reviews Clinical …, 2015 - nature.com
Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …

Regulation of inflammation in cancer by eicosanoids

ER Greene, S Huang, CN Serhan… - Prostaglandins & other lipid …, 2011 - Elsevier
Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …

M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells

M Heusinkveld, PJ de Vos van Steenwijk… - The Journal of …, 2011 - journals.aai.org
Monocytes attracted by tumor-induced chronic inflammation differentiate to APCs, the type of
which depends on cues in the local tumor milieu. In this work, we studied the influence of …

Molecular pathways: vasculogenic mimicry in tumor cells: diagnostic and therapeutic implications

DA Kirschmann, EA Seftor, KM Hardy, REB Seftor… - Clinical cancer …, 2012 - AACR
Tumor cell vasculogenic mimicry (VM) describes the functional plasticity of aggressive
cancer cells forming de novo vascular networks, thereby providing a perfusion pathway for …

[HTML][HTML] Tumor cell vasculogenic mimicry: from controversy to therapeutic promise

REB Seftor, AR Hess, EA Seftor, DA Kirschmann… - The American journal of …, 2012 - Elsevier
In 1999, The American Journal of Pathology published an article entitled “Vascular Channel
Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry,” by …

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer

G Aviello, B Romano, F Borrelli, R Capasso… - Journal of molecular …, 2012 - Springer
Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and
non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant …

Anisotropic gold nanoparticles in biomedical applications

C Kohout, C Santi, L Polito - International journal of molecular sciences, 2018 - mdpi.com
Gold nanoparticles (AuNPs) play a crucial role in the development of nanomedicine,
principally due to their unique photophysical properties and high biocompatibility. The …

Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?

G O'callaghan, A Houston - British journal of pharmacology, 2015 - Wiley Online Library
Elevated expression of COX‐2 and increased levels of PGE2 are found in numerous
cancers and are associated with tumour development and progression. Although …

Pattern-recognition receptors and gastric cancer

N Castaño-Rodríguez, NO Kaakoush… - Frontiers in …, 2014 - frontiersin.org
Chronic inflammation has been associated with an increased risk of several human
malignancies, a classic example being gastric adenocarcinoma (GC). Development of GC is …

Tumor cell vascular mimicry: Novel targeting opportunity in melanoma

MJC Hendrix, EA Seftor, REB Seftor, JT Chao… - Pharmacology & …, 2016 - Elsevier
Abstract In 1999, the American Journal of Pathology published an article, entitled “Vascular
channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry” by …