The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

The way cancer cells utilize nutrients to support their growth and proliferation is determined
by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the …

The original description of dietary methionine restriction (MR) used semipurified diets to limit
methionine intake to 20% of normal levels, and this reduction in dietary methionine …

Dietary methionine restriction (MR) produces a rapid and persistent remodeling of white
adipose tissue (WAT), an increase in energy expenditure (EE), and enhancement of insulin …

Dietary methionine restriction (MR) is well known to reduce body weight by increasing
energy expenditure (EE) and insulin sensitivity. An elevated concentration of circulating …

Obesity and diabetes are major challenges to global health, and there is an urgent need for
interventions that promote weight loss. Dietary restriction of methionine promotes leanness …

Objective Restricting dietary methionine to 0.17% produces a series of physiological
responses through coordinated transcriptional effects in liver and adipose tissue. The goal of …

This study aims to explore the influences of a methionine-restricted diet (MRD) on fat
browning and hepatic lipid accumulation in mice fed with a high-choline diet (HCD) and their …

Methionine restriction (MR) exerts many beneficial effects, such as increasing longevity,
decreasing oxidative damage and alleviating inflammatory responses. Much attention has …

Brown adipose tissue (BAT) is specialized in heat production, but its metabolism in ob/ob
mice is still a matter of debate. We aimed to verify ob/ob mice BAT using C57Bl/6 male mice …