Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1)
channel and is a common component found in the fruits of the genus Capsicum plants …

The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …

Ion channels are integral membrane proteins whose gating has been increasingly shown to
depend on the presence of the low-abundance membrane phospholipid …

Abstract Background Cancer-induced Bone Pain (CIBP) is an important factor affecting their
quality of life of cancer survivors. In addition, current clinical practice and scientific research …

The cation-permeable TRPV2 channel is important for cardiac and immune cell function.
Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few …

With sweeping advances in precision delivery systems and manipulation of the genomes
and transcriptomes of various cell types, medical biotechnology offers unprecedented …

The airway mucus barrier is a primary defensive layer at the airway surface. Mucins are the
major structural components of airway mucus that protect the respiratory tract. Respiratory …

Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible
for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced …