New hope for type 2 diabetics: Targeting insulin resistance through the immune modulation of stem cells
Y Zhao, Z Jiang, C Guo - Autoimmunity reviews, 2011 - Elsevier
The prevalence of type 2 diabetes (T2D) is increasing worldwide, highlighting the need for a
better understanding of the pathogenesis of the disease and the development of innovative …
better understanding of the pathogenesis of the disease and the development of innovative …
Role of regulatory T-cells in autoimmunity
RJ Mellanby, DC Thomas, J Lamb - Clinical science, 2009 - portlandpress.com
There has been considerable historical interest in the concept of a specialist T-cell subset
which suppresses over-zealous or inappropriate T-cell responses. However, it was not until …
which suppresses over-zealous or inappropriate T-cell responses. However, it was not until …
B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2, 3-dioxygenase
BA Johnson III, DJ Kahler, B Baban… - Proceedings of the …, 2010 - National Acad Sciences
A discrete population of splenocytes with attributes of dendritic cells (DCs) and coexpressing
the B-cell marker CD19 is uniquely competent to express the T-cell regulatory enzyme …
the B-cell marker CD19 is uniquely competent to express the T-cell regulatory enzyme …
Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes
DM Waid, GM Vaitaitis, ND Pennock… - Journal of Leucocyte …, 2008 - academic.oup.com
Although regulatory T cells (Tregs) are well described, identifying autoaggressive effector T
cells has proven more difficult. However, we identified CD4loCD40+ (Th40) cells as being …
cells has proven more difficult. However, we identified CD4loCD40+ (Th40) cells as being …
STAT3-mediated epigenetic silencing of FOXP3 in LADA T cells is regulated through HDAC5 and DNMT1
C Hou, Y Zhong, Z Wang, Z Ming, G Huang… - Clinical …, 2018 - Elsevier
In LADA patients, Tregs are reduced and FOXP3 is downregulated in CD4+ T cells, but the
etiology remains unclear. Our study included in 20 LADA patients and 20 healthy control …
etiology remains unclear. Our study included in 20 LADA patients and 20 healthy control …
[HTML][HTML] Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development
Q Leng, Y Nie, Y Zou, J Chen - BMC immunology, 2008 - Springer
Abstract Background Type I diabetes (TID) is an autoimmune disease resulting from
destruction of the insulin-producing β-cells by autoreactive T cells. Studies have shown that …
destruction of the insulin-producing β-cells by autoreactive T cells. Studies have shown that …
Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways
J Wang, J Lu, Y Lan, H Zhou, W Li, M Xiang - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Urtica dentata Hand (UDH), the root of
Laportea bulbifera (Sieb. et. Zucc.) Wedd, has been traditionally used in traditional Chinese …
Laportea bulbifera (Sieb. et. Zucc.) Wedd, has been traditionally used in traditional Chinese …
TCDD: An environmental immunotoxicant reveals a novel pathway of immunoregulation—a 30-year odyssey
NI Kerkvliet - Toxicologic pathology, 2012 - journals.sagepub.com
I was honored to be the keynote speaker at the 30th Annual Society of Toxicologic
Pathology Symposium “Toxicologic Pathology and the Immune System.” I had the …
Pathology Symposium “Toxicologic Pathology and the Immune System.” I had the …
Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: implications for the timing of …
S Bertin-Maghit, D Pang, B O'Sullivan, S Best… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE The effectiveness of tolerizing immunotherapeutic strategies, such as anti-
CD40L or dendritic cells (DCs), is greater when administered to young nonobese diabetic …
CD40L or dendritic cells (DCs), is greater when administered to young nonobese diabetic …
Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus
Type 1 diabetes mellitus (T1DM) in humans is characterized by the T-cell-dependent
destruction of the insulin producing pancreatic beta cells; however, the precise …
destruction of the insulin producing pancreatic beta cells; however, the precise …