Due to its safety, convenience, low cost and good compliance, oral administration attracts
lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory …

The importance of transition metal catalysis is exemplified by its wide range of applications,
for example in the synthesis of chemicals, natural products, and pharmaceuticals. However …

Bile acids are synthesized in the liver, stored in the gallbladder, and secreted into the
duodenum at meals. Apical sodium-dependent bile acid transporter (ASBT), an ileal Na+ …

A widely established prodrug strategy can effectively optimize the unappealing properties of
therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely uplift the …

Dendritic nanovectors-based drug delivery has gained significant attention in the past
couple of decades. Dendrimers play a crucial role in deciding the solubility of sparingly …

Nano drug delivery systems (NDDS) offer promising solution for the translation of future
nanomedicines. As bioavailability and therapeutic outcomes can be improved by altering the …

The number of lipophilic drug candidates in pharmaceutical discovery pipelines has
increased in recent years. These drugs often possess physicochemical properties that result …

Understanding and establishing a link between the physicochemical characteristics of
nanoparticles (NPs) and their biological interactions poses to be a great challenge in the …

Permeability of any pharmaceutical is critically significant for its biopharmaceutical profile,
therapeutic activities, and deciding its dosing regimen. Approximately 35% of the marketed …

New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-
drug conjugates are taking great relevance in the pharmaceutical industry due to their …