The myosin family of actin filament-based molecular motors consists of at least 20
structurally and functionally distinct classes. The human genome contains nearly 40 myosin …

▪ Abstract Cell polarity, as reflected by polarized growth and organelle segregation during
cell division in yeast, appears to follow a simple hierarchy. On the basis of physical cues …

Following homozygosity mapping in a single kindred, we identified nonsense and missense
mutations in MYO5B, encoding type Vb myosin motor protein, in individuals with microvillus …

Early in evolution, the diversification of membrane-bound compartments that characterize
eukaryotic cells was accompanied by the elaboration of molecular machineries that mediate …

Myosins are a large family of actin-based cytoskeletal motors that use energy derived from
ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have …

Plasma membrane recycling is an important process necessary for maintaining membrane
composition. The motor protein myosin Vb regulates plasma membrane recycling through its …

Major advances in understanding regulated mucin secretion from airway goblet cells have
been made in the past decade in the areas of pharmacology and basic cell biology. For …

The regulated trafficking of neurotransmitter receptors at synapses is critical for synaptic
function and plasticity. However, the molecular machinery that controls active transport of …

The Rab GTPases are the largest family of proteins regulating membrane traffic. Rab
proteins form a nidus for the assembly of multiprotein complexes on distinct vesicle …

Rab8 has a drastic effect on cell shape, but the membrane trafficking route it regulates is
poorly defined. Here, we show that endogenous and ectopically expressed Rab8 is …