The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors
together with the discovery of their endogenous ligands in the late 80s and early 90s …

Cannabis is the most commonly used illicit drug worldwide, with~ 5 million daily users
worldwide. Emerging evidence supports a number of associations between cannabis and …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Most neurodegenerative disorders (NDD s) are characterized by cognitive impairment and
other neurological defects. The definite cause of and pathways underlying the progression …

Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology
remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary …

Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

The isolation and identification of the discrete plant cannabinoids in marijuana revived
interest in analyzing historical therapeutic claims made for cannabis in clinical case studies …

Repeated injections of cannabidiol (CBD), the major non-psychotomimetic compound
present in the Cannabis sativa plant, attenuate the anxiogenic effects induced by Chronic …

Cognitive impairment is one of the most important negative consequences associated with
cannabis consumption. We found that CB1 cannabinoid receptor (CB1R) activation …