Abstract OpenProt (www. openprot. org) is the first proteogenomic resource supporting a
polycistronic annotation model for eukaryotic genomes. It provides a deeper annotation of …

Short ORFs (sORFs), that is, occurrences of a start and stop codon within 100 codons or
less, can be found in organisms of all domains of life, outnumbering annotated protein …

Long non-coding RNA (lncRNA) was originally defined as the representative of the non-
coding RNAs and unable to encode. However, recent reports suggest that some lncRNAs …

Abstract sORFs. org (http://www. sorfs. org) is a public repository of small open reading
frames (sORFs) identified by ribosome profiling (RIBO-seq). This update elaborates on the …

The emergence of small open reading frame (sORF)-encoded peptides (SEPs) is rapidly
expanding the known proteome at the lower end of the size distribution. Here, we show that …

Advances in proteomics and sequencing have highlighted many non-annotated open
reading frames (ORFs) in eukaryotic genomes. Genome annotations, cornerstones of …

In recent years, there has been increased appreciation that a whole category of proteins,
small proteins of around 50 amino acids or fewer in length, has been missed by annotation …

Background Micropeptides are small proteins with length<= 100 amino acids. Short open
reading frames that could produces micropeptides were traditionally ignored due to …

Next-generation sequencing (NGS) technologies have greatly expanded the size of the
known transcriptome. Many newly discovered transcripts are classified as long noncoding …

An exciting emerging topic in the noncoding RNA (ncRNA) field is the discovery of short
peptides called micropeptides (≤ 100 amino acids), whose novel therapeutic opportunities …