Hepatocellular carcinoma: clinical frontiers and perspectives
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is
currently the main event leading to death in patients with cirrhosis. Evolving information …
currently the main event leading to death in patients with cirrhosis. Evolving information …
Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design
JM Llovet, V Hernandez-Gea - Clinical cancer research, 2014 - AACR
Hepatocellular carcinoma (HCC) is a major health problem. Most patients with HCC
experience a recurrence after resection/ablation or are diagnosed at advanced stages …
experience a recurrence after resection/ablation or are diagnosed at advanced stages …
Liver cancer: approaching a personalized care
The knowledge and understanding of all aspects of liver cancer [this including
hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA)] have …
hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA)] have …
[HTML][HTML] Hepatocellular carcinoma review: current treatment, and evidence-based medicine
A Raza, GK Sood - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide. Multiple
treatment options are available for HCC including curative resection, liver transplantation …
treatment options are available for HCC including curative resection, liver transplantation …
Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib
M Reig, F Torres, C Rodriguez-Lope, A Forner… - Journal of …, 2014 - Elsevier
Background & Aims There are no clinical data/markers to predict improved survival in
patients with hepatocellular carcinoma treated with sorafenib. Majority of sorafenib adverse …
patients with hepatocellular carcinoma treated with sorafenib. Majority of sorafenib adverse …
Systemic therapy for hepatocellular carcinoma: the issue of treatment stage migration and registration of progression using the BCLC-refined RECIST
M Reig, A Darnell, A Forner, J Rimola… - Seminars in liver …, 2014 - thieme-connect.com
Recent advancements have improved the management of patients with liver cancer. Results
of studies have informed how to stage and decide the optimal treatment option for each …
of studies have informed how to stage and decide the optimal treatment option for each …
S0941: a phase 2 SWOG study of sorafenib and erlotinib in patients with advanced gallbladder carcinoma or cholangiocarcinoma
AB El-Khoueiry, C Rankin, AB Siegel, S Iqbal… - British journal of …, 2014 - nature.com
Background: Gallbladder cancers and cholangiocarcinomas make up a heterogenous group
of tumours with a poor prognosis in advanced stages. On the basis of evidence of …
of tumours with a poor prognosis in advanced stages. On the basis of evidence of …
[HTML][HTML] Molecular targeted therapy for hepatocellular carcinoma: current and future
JW Shin, YH Chung - World journal of gastroenterology: WJG, 2013 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most frequent tumors worldwide. The majority
of HCC cases occur in patients with chronic liver disease. Despite regular surveillance to …
of HCC cases occur in patients with chronic liver disease. Despite regular surveillance to …
Drug therapy for advanced-stage liver cancer
M Peck-Radosavljevic - Liver cancer, 2014 - karger.com
Liver cancer was traditionally treated by surgery or interventional ablative treatments, or, if
these options were not feasible, by best supportive care. Since 2008, systemic therapy with …
these options were not feasible, by best supportive care. Since 2008, systemic therapy with …
A phase II study of cixutumumab (IMC-A12, NSC742460) in advanced hepatocellular carcinoma
GK Abou-Alfa, M Capanu, EM O'Reilly, J Ma… - Journal of …, 2014 - Elsevier
Background & Aims IGF-IR is implicated in hepatic carcinogenesis. This and preliminary
evidence of biological activity of anti-IGF-1R monoclonal antibody cixutumumab in phase I …
evidence of biological activity of anti-IGF-1R monoclonal antibody cixutumumab in phase I …