The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …

In this chapter we will review both the rationale and experimental design for using
Heterogeneous Stock (HS) populations for fine-mapping of complex traits in mice and rats …

Abstract The Rat Genome Database (RGD, https://rgd. mcw. edu) has evolved from simply a
resource for rat genetic markers, maps, and genes, by adding multiple genomic data types …

A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …

Heterogeneous Stock (HS) rats are a genetically diverse outbred rat population that is
widely used for studying genetics of behavioral and physiological traits. Mapping …

Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …

Objective Obesity is influenced by genetic and environmental factors. Despite the success of
human genome‐wide association studies, the specific genes that confer obesity remain …

Abstract The Collaborative Cross (CC) is a mouse genetic reference population whose
range of applications includes quantitative trait loci (QTL) mapping. The design of a CC QTL …

Many personality traits are influenced by genetic factors. Rodents models provide an
efficient system for analyzing genetic contribution to these traits. Using 1,246 adolescent …

Gene transcription profiles across tissues are largely defined by the activity of regulatory
elements, most of which correspond to regions of accessible chromatin. Regulatory element …