Liposomes: Structure, composition, types, and clinical applications

H Nsairat, D Khater, U Sayed, F Odeh, A Al Bawab… - Heliyon, 2022 - cell.com
Liposomes are now considered the most commonly used nanocarriers for various potentially
active hydrophobic and hydrophilic molecules due to their high biocompatibility …

[HTML][HTML] Recent advances in using liposomes for delivery of nucleic acid-based therapeutics

H Nsairat, W Alshaer, F Odeh, E Esawi, D Khater… - OpenNano, 2023 - Elsevier
Nucleic acid therapeutics are rapidly expanding because of recent advancements in
production and purification. This class of therapeutics may change the field of disease …

Micro‐nanocarriers based drug delivery technology for blood‐brain barrier crossing and brain tumor targeting therapy

L Wang, Y Shi, J Jiang, C Li, H Zhang, X Zhang… - Small, 2022 - Wiley Online Library
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …

Lipid-based nanocarriers for neurological disorders: a review of the state-of-the-art and therapeutic success to date

BA Witika, MS Poka, PH Demana, SK Matafwali… - Pharmaceutics, 2022 - mdpi.com
Neurodegenerative disorders including Alzheimer's, Parkinson's, and dementia are chronic
and advanced diseases that are associated with loss of neurons and other related …

Liposome bilayer stability: Emphasis on cholesterol and its alternatives

H Nsairat, AA Ibrahim, AM Jaber… - Journal of Liposome …, 2024 - Taylor & Francis
Liposomes are spherical lipidic nanocarriers composed of natural or synthetic phospholipids
with a hydrophobic bilayer and aqueous core, which are arranged into a polar head and a …

Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications …

S Javed, B Mangla, Y Almoshari, MH Sultan… - Nanotechnology …, 2022 - degruyter.com
The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid
nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and …

Role of siRNA-based nanocarriers for the treatment of neurodegenerative diseases

N Mishra, S Ashique, A Garg, VK Rai, K Dua… - Drug Discovery …, 2022 - Elsevier
Neurodegenerative disorders (NDs) lead to the progressive degeneration of the structural
and physiological functions of the central and peripheral nervous systems, resulting in …

Preparation of solid lipid nanoparticles of cinnamaldehyde and determination of sustained release capacity

J Chen, S Li, Q Zheng, X Feng, W Tan, K Feng, Y Liu… - Nanomaterials, 2022 - mdpi.com
Natural plant essential oils cannot be applied on a large scale due to their high volatility,
easy deactivation, etc. This study provides a new method to prepare a long-lasting, slow …

Dysregulated lipid metabolism in TMZ-resistant glioblastoma: Pathways, proteins, metabolites and therapeutic opportunities

TJ Kao, CL Lin, WB Yang, HY Li, TI Hsu - Lipids in Health and Disease, 2023 - Springer
Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with limited treatment
options, such as the chemotherapeutic agent, temozolomide (TMZ). However, many GBM …

Nanocarriers for drug delivery: an overview with emphasis on vitamin D and K transportation

A Crintea, AG Dutu, A Sovrea, AM Constantin… - Nanomaterials, 2022 - mdpi.com
Mounting evidence shows that supplementation with vitamin D and K or their analogs
induces beneficial effects in various diseases, eg, osteoarticular, cardiovascular, or …