Diabetic retinopathy (DR) is a well-known microvascular complication related to
inflammation. Mcc950 is a potent and specific inhibitor of the NLRP3 inflammasome but its …

Circulating monocytes and tissue macrophages play complex roles in the pathogenesis of
hypertension, a highly prevalent disease associated with catastrophic cardiovascular …

Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular
disease. As a multifactorial and systemic disease that involves multiple organs and systems …

Abstract Purpose of Review In recent years, a vast body of evidence has accumulated
indicating the role of the immune system in the regulation of blood pressure and modulation …

Cardiovascular fibrosis refers to the scar tissue that develops in the injured heart and blood
vessels from an aberrant wound healing response to organ injury or insult. Established …

Hypertension is the primary cause of cardiovascular mortality. Despite multiple existing
treatments, only half of those with the disease achieve adequate control. Therefore …

Background/Aims: Angiotensin (Ang) II plays vital roles in vascular inflammation and
remodeling in hypertension. Phenotypic transformation of vascular smooth muscle cells …

Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome
activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be …

Inflammasome mediates the activation of caspase-1, which promotes the secretion of
proinflammatory cytokines. In this work, we aimed to investigate whether natural compounds …

Aims Hypertension is one of the major causes of cardiac damage. In this study, the effects of
resveratrol supplementation and regular exercise on hypertension-induced cellular stress …