Background: Inflammation is a key feature of aldosterone-induced vascular damage and
dysfunction, but molecular mechanisms by which aldosterone triggers inflammation remain …

Fibrosis is the major pathological feature of chronic kidney disease (CKD). Aloe-emodin
(AE), one of the main active compounds in Rhubarb, is widely used for renal protection …

Abstract ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult
kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim …

Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia. High-
serum uric acid can trigger renal inflammation. The inflammasome family has several …

Growing evidence points out the importance of nucleotide‐binding oligomerization domain
leucine‐rich repeat and pyrin domain‐containing protein 3 (NLRP3) inflammasome in the …

Aldosterone excess aggravates endothelial dysfunction in diabetes and hypertension by
promoting the increased generation of reactive oxygen species, inflammation, and insulin …

IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood
pressure and end-organ damage is unknown. We examined the role of IL-18 in the …

Preeclampsia (PE) is a pregnancy-specific multisystem disorder and is associated with
maladaptation of the maternal cardiovascular system and abnormal placentation. One of the …

In recent years, the mechanism of cell death has become a hotspot in research on the
pathogenesis and treatment of cardiovascular disease (CVD). Different cell death modes …

Metabolic syndrome (MS) is a group of complex metabolic disorders syndrome, which refers
to the pathological state of metabolism disorder of protein, fat, carbohydrate and other …