Focal adhesion kinase (FAK) is a protein tyrosine kinase that regulates cellular adhesion,
motility, proliferation and survival in various types of cells. Interestingly, FAK is activated …

Endothelial cells (ECs) form cell-cell adhesive junctional structures maintaining vascular
integrity. This barrier is dynamically regulated by vascular endothelial growth factor (VEGF) …

Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …

It is twenty years since Focal Adhesion Kinase (FAK) was found to be overexpressed in
many types of human cancer. FAK plays an important role in adhesion, spreading, motility …

Chemoresistance is a serious limitation of cancer treatment. Until recently, almost all the
work done to study this limitation has been restricted to tumour cells. Here we identify a …

Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor growth and
metastasis, via actions on both tumor and stromal cells. In this paper, we show that vascular …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant
malignancy and is characterized by a dense, desmoplastic stroma that modulates PDAC …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …

Angiogenesis, the formation of new blood vessels from pre‐existing ones, is essential for
tumour development. It is initiated and regulated by growth factors via their surface …

Angiogenesis is de novo capillary outgrowth from pre-existing blood vessels. This process
not only is crucial for normal development, but also has an important role in supplying …