Targeting misfolding and aggregation of the amyloid-β peptide and mutant p53 protein using multifunctional molecules

L Grcic, G Leech, K Kwan, T Storr - Chemical Communications, 2024 - pubs.rsc.org
Biomolecule misfolding and aggregation play a major role in human disease, spanning from
neurodegeneration to cancer. Inhibition of these processes is of considerable interest, and …

Gene Editing with Artificial DNA Scissors

A Kellett, A Gibney - Chemistry–A European Journal - Wiley Online Library
Artificial metallo‐nucleases (AMNs) are small molecule DNA cleavage agents, also known
as DNA molecular scissors, and represent an important class of chemotherapeutic with high …