Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Organ‐and tissue‐level biological functions are intimately linked to microscale cell–cell
interactions and to the overarching tissue architecture. Together, biofabrication and …

Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

Liver disease is a major global health-care problem, affecting an estimated 844 million
people worldwide. Despite this substantial burden, therapeutic options for liver disease …

Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-
directed process of autophagy. An organelle-selective form of this process (macrolipophagy) …

Contacts between organelles create microdomains that play major roles in regulating key
intracellular activities and signaling pathways, but whether they also regulate systemic …

The organic anion transporting polypeptides OATP1B1 and OATP1B3 are membrane
proteins that mediate uptake of drugs into the liver for subsequent conjugation and biliary …

Over 65% of people with obesity display the metabolic-associated fatty liver disease
(MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The …