Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

In optogenetics, light-sensitive proteins are specifically expressed in target cells and light is
used to precisely control the activity of these proteins at high spatiotemporal resolution …

Blue light using flavin (BLUF) photoreceptors respond to light via one of nature's smallest
photo-switching domains. Upon photo-activation, the flavin cofactor in the BLUF domain …

Fluorescent reporters are essential components for the design of optical biosensors that are
able to image intracellular analytes in living cells. Herein, we describe the development of …

Current approaches for optogenetic control of transcription do not mimic the activity of
endogenous transcription factors, which act at numerous sites in the genome in a complex …

Molecular switches alterable between two stable states by environmental stimuli, such as
light and temperature, offer the potential for controlling biological functions. Here, we report …

Nature provides an array of proteins that change conformation in response to light. The
discovery of a complementary array of proteins that bind only the light-state or dark-state …

The precise spatiotemporal regulation of protein synthesis is essential for many complex
biological processes such as memory formation, embryonic development, and tumor …

Although widely used in the detection and characterization of protein–protein interactions,
Y2H screening has been under-used for the engineering of new optogenetic tools or the …

The design of new optogenetic tools for controlling protein function would be facilitated by
the development of protein scaffolds that undergo large, well-defined structural changes …