Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system
(CNS) leading to the progressive destruction of the myelin sheath surrounding axons. It can …

Th17 cells reactive to the enteric microbiota are central to the pathogenesis of certain types
of inflammatory bowel disease. However, Th17 cells display substantial developmental …

We have previously reported the molecular signature of murine pathogenic TH17 cells that
induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that …

Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …

The differentiation and function of IL-17–producing Th17 cells are tightly regulated by
specific transcription factors and cytokines, which are the key participants in the …

Abstract Th17 cells and interleukin‐17 (IL‐17) have been found to play an important role in
the pathology of multiple sclerosis (MS) and its animal model, experimental autoimmune …

Mature T helper (Th) effector cells originate following antigen recognition by naive T
precursors. The maturation process is accompanied by the acquisition of specific effector …

The role of IFN‐γ in the pathogenesis of autoimmune diseases is controversial. Although
Th1 cells can induce experimental autoimmune encephalomyelitis (EAE), IFN‐γ can …

Abstract γδ T lymphocytes are programmed into distinct IFN-γ–producing CD27+(γδ27+)
and IL-17–producing CD27−(γδ27−) subsets that play key roles in protective or pathogenic …