Current and Emerging Treatment Options for Multidrug Resistant Escherichia coli Urosepsis: A Review

MM Walker, JA Roberts, BA Rogers, PNA Harris… - Antibiotics, 2022 - mdpi.com
Escherichia coli is a versatile commensal and pathogenic member of the human microflora.
As the primary causative pathogen in urosepsis, E. coli places an immense burden on …

Achieving ultrasensitive chromogenic probes for rapid, direct detection of carbapenemase-producing bacteria in sputum

W Li, J Wang, C Li, Z Zong, J Zhao, H Gao, D Liu - JACS Au, 2022 - ACS Publications
Carbapenemase-producing bacteria (CPB) stand as the most dangerous “superbugs” in the
clinic. Rapid point-of-care (POC) detection of CPB in clinical samples is key to timely and …

Outer Membrane Proteins and Efflux Pumps Mediated Multi-Drug Resistance in Salmonella: Rising Threat to Antimicrobial Therapy

SD Akshay, VK Deekshit, J Mohan Raj… - ACS Infectious …, 2023 - ACS Publications
Despite colossal achievements in antibiotic therapy in recent decades, drug-resistant
pathogens have remained a leading cause of death and economic loss globally. One such …

Relebactam restores susceptibility of resistant Pseudomonas aeruginosa and Enterobacterales and enhances imipenem activity against chromosomal AmpC …

DW Hilbert, CA DeRyke, M Motyl, M Hackel, K Young - BMC microbiology, 2023 - Springer
Background Carbapenem-resistant bacteria are an increasing problem in clinical practice;
thus, it is important to identify β-lactamase inhibitors (eg, relebactam) that can restore …

Management of highly resistant Gram-negative infections in the intensive care unit in the era of novel antibiotics

CJ Clancy, MH Nguyen - Infectious Disease Clinics, 2022 - id.theclinics.com
Background It is important for intensivists to understand inducible AmpC b-lactamase
production, and when to consider it in making treatment decisions. Inducible expression of …

Transferable AmpCs in Klebsiella pneumoniae: interplay with peptidoglycan recycling, mechanisms of hyperproduction, and virulence implications

IM Barceló, M Escobar-Salom, G Cabot… - Antimicrobial agents …, 2024 - Am Soc Microbiol
Chromosomal and transferable AmpC β-lactamases represent top resistance mechanisms
in different gram-negatives, but knowledge regarding the latter, mostly concerning regulation …

Antimicrobial treatment of Morganella morganii invasive infections: Systematic review

RZ Zaric, S Jankovic, M Zaric, M Milosavljevic… - Indian journal of medical …, 2021 - Elsevier
Background Morganella morganii is a Gram-negative, rod-shaped, facultative anaerobic
bacillus divided into two subspecies, morganii and sibonii. Previously classified as Proteus …

[HTML][HTML] Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM): epidemiology and antimicrobial resistance burden from a cohort of 27 …

M Boattini, G Bianco, LI Llorente, LA Acero… - International Journal of …, 2024 - Elsevier
Abstract Introduction The ESCPM group (Enterobacter species including Klebsiella
aerogenes-formerly Enterobacter aerogenes, Serratia species, Citrobacter freundii complex …

[HTML][HTML] One system for all: is mass spectrometry a future alternative for conventional antibiotic susceptibility testing?

M Welker, A Van Belkum - Frontiers in microbiology, 2019 - frontiersin.org
The two main pillars of clinical microbiological diagnostics are the identification of potentially
pathogenic microorganisms from patient samples and the testing for antibiotic susceptibility …

[HTML][HTML] Antimicrobial-resistant Enterobacter cloacae complex strains isolated from fresh vegetables intended for raw consumption and their farm environments in the …

A Pintor-Cora, Á Alegría, J Ramos-Vivas… - LWT, 2023 - Elsevier
Antimicrobial resistance is a global concern with significant public health implications. We
investigated the role of fresh vegetables and their cultivation environments as reservoirs for …