Potential Alzheimer's disease drug targets identified through microglial biology research
I Lepiarz-Raba, T Hidayat, AJ Hannan… - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Microglia, the primary immune cells in the brain, play multifaceted roles in
Alzheimer's disease (AD). Microglia can potentially mitigate the pathological progression of …
Alzheimer's disease (AD). Microglia can potentially mitigate the pathological progression of …
Development of Granzyme B-targeted Smart Positron Emission Tomography Probes for Monitoring Tumor Early Response to Immunotherapy
J Fu, H Xi, S Cai, Y Peng, Q Liu, L Qiu, J Lin - ACS nano, 2024 - ACS Publications
Granzyme B is an immune-related biomarker that closely correlates with cytotoxic T
lymphocytes (CTLs), and hence detecting the expression level of granzyme B can provide a …
lymphocytes (CTLs), and hence detecting the expression level of granzyme B can provide a …
Human brain organoids containing microglia that have arisen innately adapt to a β-amyloid challenge better than those in which microglia are integrated by co-culture
TJ Wenzel, JD Desjarlais, DD Mousseau - Stem Cell Research & Therapy, 2024 - Springer
Background Alzheimer disease (AD) is a heterogenous and multifactorial disease, and its
pathology is partly driven by microglia and their activated phenotype. Brain organoids (BOs) …
pathology is partly driven by microglia and their activated phenotype. Brain organoids (BOs) …
[HTML][HTML] Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
B Rizoska, O Zachrisson, P Appelkvist… - Molecular and Cellular …, 2024 - Elsevier
Amyloid beta (Aβ) peptides, which aggregate to form neocortical plaques in Alzheimer's
disease, exist in states that range from soluble monomers and oligomers/protofibrils to …
disease, exist in states that range from soluble monomers and oligomers/protofibrils to …
[HTML][HTML] Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimer's disease mouse …
A Orlowski, J Karippaparambil, JM Paumier, S Ghanta… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Lysosomes and related precursor organelles robustly build up in swollen axons that
surround amyloid plaques and disrupted axonal lysosome transport has been implicated in …
surround amyloid plaques and disrupted axonal lysosome transport has been implicated in …
Microglia Purinergic Receptor-Mediated Neuroinflammation in Alzheimer's Disease
KS Heavener - 2024 - search.proquest.com
Neurodegeneration involves a complicated cascade of homeostatic dysfunction that
converges on neuron loss and cognitive decline, involving complex immune, metabolic, and …
converges on neuron loss and cognitive decline, involving complex immune, metabolic, and …
Small Molecule Decoy of Amyloid-β Aggregation Blocks Activation of Microglia-Like Cells
Background: Aggregated forms of the amyloid-ß (Aß) peptides which form protofibrils and
fibrils in the brain are signatures of Alzheimer's disease (AD). Aggregates are also …
fibrils in the brain are signatures of Alzheimer's disease (AD). Aggregates are also …
[HTML][HTML] Microglia and amyloid plaque formation in Alzheimer's disease–Evidence, possible mechanisms, and future challenges
S Fruhwürth, H Zetterberg, SR Paludan - Journal of Neuroimmunology, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline
that severely affects patients and their families. Genetic and environmental risk factors, such …
that severely affects patients and their families. Genetic and environmental risk factors, such …