The prevalence of metabolic diseases is growing worldwide. Accumulating evidence
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …

Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

Introduction Heart failure (HF) is a heterogeneous clinical syndrome and affects millions of
people all over the world. HF occurs when the cardiac overload and injury, which is a …

Background Obesity associated type 2 diabetes mellitus is a metabolic disorder; however,
the etiology of obesity associated type 2 diabetes mellitus remains largely unknown. There …

Metabolic regulation of cerebrovascular tone directs blood flow to areas of increased
neuronal activity and during disease states partially compensates for insufficient perfusion …

Cell metabolism increases during carcinogenesis. Yet, intracellular pH in solid cancer tissue
is typically maintained equal to or above that of normal tissue. This is achieved through …

Genome-wide association studies have revealed an association between variation at the
SLC4A7 locus and blood pressure. SLC4A7 encodes the electroneutral Na+/HCO 3− co …

The SLC4 family Cl−/HCO 3-cotransporters (NBCe1, NBCe2, NBCn1, and NBCn2)
contribute to a variety of vital physiological processes including pH regulation and epithelial …

Despite a widespread expression pattern in the central nervous system, the role of the
sodium bicarbonate cotransporter NBCn1/Slc4a7 has not been investigated for locomotor …

GDF1 plays an important role in left–right patterning and genetic mutations in the coding
region of GDF1 are associated with congenital heart disease (CHD). However, the genetic …