Forensic identification of sudden cardiac death: a new approach combining metabolomics and machine learning

J Cao, X Wei, MF Liu, GS An, J Li, QX Du… - Analytical and …, 2023 - Springer
The determination of sudden cardiac death (SCD) is one of the difficult tasks in the forensic
practice, especially in the absence of specific morphological changes in the autopsies and …

From flesh to bones: Multi‐omics approaches in forensic science

N Procopio, A Bonicelli - Proteomics, 2024 - Wiley Online Library
Recent advancements in omics techniques have revolutionised the study of biological
systems, enabling the generation of high‐throughput biomolecular data. These innovations …

Exploring metabolic alterations associated with death from asphyxia and the differentiation of asphyxia from sudden cardiac death by GC-HRMS-based untargeted …

K Zhang, H Yan, R Liu, P Xiang, K Deng… - … of Chromatography B, 2021 - Elsevier
The determination of cause of death is one of the most important tasks in forensic practice.
However, asphyxia is a difficult cause of death to determine, especially when the deceased …

[HTML][HTML] The use of untargeted and widely targeted metabolomics to distinguish between asphyxia and sudden cardiac death as the cause of death in rats: A …

K Zhang, Y Tuo, R Liu, H Yan, P Xiang, Z Wang… - Arabian Journal of …, 2022 - Elsevier
It is important to determine the cause of death in the case of asphyxia. However, it is difficult
to conclude death by asphyxia, especially when the deceased has underlying heart disease …

Salvia miltiorrhiza and the Volatile of Dalbergia odorifera Attenuate Chronic Myocardial Ischemia Injury in a Pig Model: A Metabonomic Approach for the Mechanism …

R Lin, F Mu, Y Li, J Duan, M Zhao… - Oxidative Medicine …, 2021 - Wiley Online Library
Salvia miltiorrhiza (SM) coupled with Dalbergia odorifera (DO) has been used to relieve
cardiovascular diseases in China for many years. Our previous studies have integrated that …

The use of gas chromatography coupled with high-resolution mass spectrometry-based untargeted metabolomics to discover metabolic changes and help in the …

K Zhang, H Yan, R Liu, P Xiang, J Zhang, K Deng… - ACS …, 2021 - ACS Publications
The determination of cause of death (COD) is one of the most important tasks in forensic
practice and is mainly based on macroscopical and microscopical morphological signatures …

Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver–Cardiac Crosstalk Metabolomics Study

W Rong, J Li, D Pan, Q Zhou, Y Zhang, Q Lu, L Wang… - Biomolecules, 2022 - mdpi.com
Leonurine has been shown to have excellent anti-myocardial ischemia effects. Our previous
studies suggested that cardiac protection by leonurine during myocardial ischemia …

代谢组学在心脏性猝死鉴定中的应用前景及展望.

谷祯, 牛佳佳, 安国帅, 杜秋香, 曹洁… - Journal of Forensic …, 2021 - search.ebscohost.com
在猝死案例中, 心脏性猝死的预防及猝死发生后死因鉴定一直是难点问题. 因此,
心脏性猝死的临床研究和法医病理学鉴定具有重要意义. 近年来, 代谢组学逐渐发展成为生命 …

Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy

W Rong, J Li, L Wang, S Luo, T Liang… - Frontiers in …, 2022 - frontiersin.org
Background: Leonurus japonicus Houtt. has an obvious efficacy on cardiovascular diseases.
As the most representative component in the herb, leonurine has attracted increasing …

Association of N-acetyl asparagine with QTc in diabetes: a metabolomics study

G Gravina, MYY Moey, E Prifti, F Ichou, O Bourron… - Biomedicines, 2022 - mdpi.com
Changes in the cardio-metabolomics profile and hormonal status have been associated with
long QT syndrome, sudden cardiac death and increased mortality. The mechanisms …