Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer

KR Sekhar, DN Hanna, S Cyr, JJ Baechle, S Kuravi… - Scientific Reports, 2022 - nature.com
Papillary thyroid carcinoma (PTC) demonstrates significantly reduced patient survival with
metastatic progression. Tumor progression can be influenced by metabolism, including …

The composites of triple-helix glucan nanotubes/selenium nanoparticles target hepatocellular carcinoma to enhance ferroptosis by depleting glutathione and …

L Cai, S Zhou, B Yu, E Zhou, Y Zheng… - Chemical Engineering …, 2022 - Elsevier
Exacerbating oxidative stress has become a promising strategy for effective cancer therapy.
However, the hyperactive antioxidant systems in tumor cells neutralize this effect, reducing …

Stratification of follicular thyroid tumours using data‐independent acquisition proteomics and a comprehensive thyroid tissue spectral library

Y Sun, L Li, Y Zhou, W Ge, H Wang, R Wu… - Molecular …, 2022 - Wiley Online Library
Thyroid nodules occur in about 60% of the population. A major challenge in thyroid nodule
diagnosis is to distinguish between follicular adenoma (FA) and carcinoma (FTC). Here, we …

Ferroptosis-related lncRNA signature predicts prognosis and immunotherapy efficacy in cutaneous melanoma

Y Xu, Y Chen, Z Niu, Z Yang, J Xing, X Yin, L Guo… - Frontiers in …, 2022 - frontiersin.org
Purpose Ferroptosis-related lncRNAs are promising biomarkers for predicting the prognosis
of many cancers. However, a ferroptosis-related signature to predict the prognosis of …

Targeting different programmed cell death processes as therapeutic modalities for thyroid cancer

S Rajabi - Frontiers in Endocrinology, 2023 - frontiersin.org
Ferroptosis, as a novel form of programmed cell death (PCD), has been shown to have
association with thyroid cancer (1). Ren et al. conducted a study that included 497 thyroid …

[HTML][HTML] Anti-Ferroptosis: A Promising Therapeutic Method for Thyroid Cancer

R Hu, Z Shi, J Yang, Y Ren, X Li - Frontiers in Bioscience-Landmark, 2024 - imrpress.com
At present, many problems remain to be solved in studying the pathogenesis of thyroid
cancer. Ferroptosis is a programmed cell death mode discovered in recent years, and many …

Simvastatin Inhibits Endometrial Cancer Malignant Behaviors by Suppressing RAS/Mitogen‐Activated Protein Kinase (MAPK) Pathway‐Mediated Reactive Oxygen …

D Zhou, Q Wu, H Qiu, M Li, Y Ji - … ‐Based Complementary and …, 2022 - Wiley Online Library
This paper was designed to explore the function of simvastatin as a chemotherapeutic drug
on the endometrial cancer (EC) cell proliferation, invasion, and ferroptosis. Firstly, a number …

Identification of a lipid metabolism-associated gene signature predicting survival in breast cancer

M Gong, X Liu, W Yang, H Song, X Zhao… - … Journal of General …, 2021 - Taylor & Francis
Background Cancer metabolism and specifically lipid metabolism play an important role in
breast cancer (BC) progression and metastasis. However, the role of lipid metabolism …

Construction of a prognostic model in lung adenocarcinoma based on ferroptosis-related genes

M Liang, M Chen, Y Zhong, S Singh, S Singh - Frontiers in Genetics, 2021 - frontiersin.org
Background: Lung adenocarcinoma is one of the most common malignant tumors of the
respiratory system, ranking first in morbidity and mortality among all cancers. This study aims …

TIPARP as a prognostic biomarker and potential immunotherapeutic target in male papillary thyroid carcinoma

J Zhang, X Zhou, F Yao, JL Zhang, Q Li - Cancer Cell International, 2024 - Springer
Background Male patients with papillary thyroid carcinoma (PTC) tend to have poorer
prognosis compared to females, partially attributable to a higher rate of lymph node …