With increasing age, structural changes occur in the eye and brain. Neuronal death,
inflammation, vascular disruption, and microglial activation are among many of the …

Highlights•AD disproportionally affects women in the development, progression and clinical
presentation of AD.•Our review summarized sex differences in biological change of AD from …

Iron imbalance in the brain negatively affects brain function. With aging, iron levels increase
in the brain and contribute to brain damage and neurological disorders. Changes in the …

Insulin‐like growth factor‐I (IGF‐I) signaling plays a key role in neuroinflammation. Here we
show that IGF‐1 also regulates phagocytosis of reactive astrocytes through p110α isoform of …

Neurodegenerative diseases are a leading cause of death worldwide with no cures
identified. Thus, there is a critical need for preventative measures and treatments as the …

Transcript levels of cytokines and SERPINA3 have been used to define a substantial subset
(40%) of individuals with schizophrenia with elevated inflammation and worse …

The mutation and overexpression of the alpha-synuclein protein (αSyn), described as
synucleinopathy, is associated with Parkinson's disease (PD)-like pathologies. A higher …

Dietary interventions with bioactive compounds have been found to suppress the
accumulation of senescent cells and senescence-associated secretory phenotypes …

Aging is a complex process that produces profound effects on the brain. Although a number
of external factors can promote the initiation and progression of brain aging, peripheral and …

The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …