NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and
transformed cells, being one of the main executors of cell death in the immune system. NK …

Publisher Summary This chapter provides an overview of how diverse mechanisms of
immunoediting preserve positive features of the immune stromal environment that facilitate …

Mature natural killer (NK) cells use Ca2+-dependent granule exocytosis and release of
cytotoxic proteins, Fas ligand (FasL), and membrane-bound or secreted cytokines (tumor …

NK-92, a highly cytotoxic, interleukin-2 (IL-2)-dependent human natural killer (NK) cell line,
has been of interest for basic and translational research. We report on a comprehensive …

Background: Current cytotoxic assays, including Cr release and fluorescent assays, do not
directly measure the proportion of target cells which are killed by apoptosis. Cell‐mediated …

While chemotherapy and radiotherapy remain the first-line approaches for the management
of most unresectable tumors, immunotherapy has emerged in the past two decades as a …

Killer cell Ig-like receptor (KIR) 2DL4 (2DL4, CD158d) was previously described as the only
KIR expressed by every human NK cell. It is also structurally atypical among KIRs because it …

Curcumin has long been known to posses medicinal properties and recent scientific studies
have shown its efficacy in treating cancer. Curcumin is now considered to be a promising …

For targets that are homogenously expressed, such as CD19 on cells of the B lymphocyte
lineage, immunotherapies can be highly effective. Targeting CD19 with blinatumomab, a …

NK cells have the capacity to spontaneously kill tumor cell lines, in particular cell lines of
hemopoietic origin. In contrast, they do not generally kill nontransformed autologous cells …