Introduction Buprenorphine is a frequently used medication for opioid use disorder and
misunderstanding buprenorphine's unique pharmacology has historically complicated …

Receptor theory predicts that fixed-proportion mixtures of a competitive, reversible agonist
(eg, fentanyl) and antagonist (eg, naltrexone) at a common receptor [eg, mu-opioid receptors …

The opioid epidemic is an ongoing public health crisis, and the United States health system
is overwhelmed with increasing numbers of opioid-related overdoses. Methocinnamox …

Opioids are commonly prescribed to address intense, ongoing pain associated with cancer,
as well as long-lasting noncancer-related pain when alternative methods have proven …

Patients with chronic non-cancer pain (CNCP) often use opioids for long periods of time.
This may lead to opioid use disorder (OUD) and psychiatric symptoms: mainly depression …

Introduction Adult cancer pain is a disease state battled on a global scale. Proper pain
management is essential to prevent health complications and promote patient well-being …

1. Background Chronic noncancer pain (CNCP) is commonly defined as any chronic pain
syndrome not related to cancer that persists for over 3 to 6 months. 107 CNCP has an …

Objective Medically treated opioid overdoses identify a population at high risk of subsequent
mortality and need for treatment. This study reports on medically treated opioid overdose …

Most patients with cancer-related pain are managed using opioids; cancer-related pain in
the setting of pregnancy can be challenging to address owing to risk to the fetus associated …

Opioids, which are widely used for the treatment of chronic pain, have an analgesic effect by
mainly activating mu-opioid receptor (MOR). Paradoxically, a high dose of naloxone, non …