The comorbidity of depression and addiction has become a serious public health issue, and
the relationship between these two disorders and their potential mechanisms has attracted …

Drug addiction remains a key biomedical challenge facing current neuroscience research. In
addition to neural mechanisms, the focus of the vast majority of studies to date, astrocytes …

Recent studies have implicated the ethanol metabolite, acetic acid, as neuroactive, perhaps
even more so than ethanol itself. In this study, we investigated sex-specific metabolism of …

Glutamate transmission is an important mediator of the development of substance use
disorders, particularly with regard to relapse. The present review summarizes the changes in …

Despite evidence that morphine-related pathologies reflect adaptations in NAc glutamate
signaling, substantial gaps in basic information remain. The current study examines the …

Comorbid anxiety and depressive symptoms in chronic pain are a common health problem,
but the underlying mechanisms remain unclear. Previously, we have demonstrated that …

Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic
glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction …

Dysregulation of glutamatergic synapses plays an important role in the pathogenesis of
neurological diseases. In addition to mediating excitatory synaptic transmission …

Experimental studies on the pathogenetic process of paclitaxel-induced neuropathic pain
(PINP) have been initially carried out, but PINP still has no effective therapy. Recently …

Cross talk between both pre-and postsynaptic components of glutamatergic
neurotransmission plays a crucial role in orchestrating a multitude of brain functions …