Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway
For millions of years, plants evolve plenty of structurally diverse secondary metabolites (SM)
to support their sessile lifestyles through continuous biochemical pathway innovation. While …
to support their sessile lifestyles through continuous biochemical pathway innovation. While …
Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …
[HTML][HTML] Interpol Review of Drug Analysis 2019-2022
D Love, NS Jones - Forensic Science International: Synergy, 2023 - ncbi.nlm.nih.gov
Improved methods of analysis, ie, faster, more discriminatory, more sensitive, less costly,
etc., are needed for all abused substances. Additionally, standard analytical data are …
etc., are needed for all abused substances. Additionally, standard analytical data are …
Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)
IM Menéndez-Perdomo, PJ Facchini - Scientific Reports, 2023 - nature.com
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized
metabolites found mainly in members of the order Ranunculales, including opium poppy …
metabolites found mainly in members of the order Ranunculales, including opium poppy …
[HTML][HTML] Phytochemical analysis and in vitro and in vivo antioxidant properties of Plagiorhegma dubia Maxim as a medicinal crop for diabetes treatment
H Sun, M Chen, X He, Y Sun, J Feng, X Guo, L Li… - Arabian Journal of …, 2023 - Elsevier
In traditional medicine, Plagiorhegma dubia Maxim (PD) is used to treat diabetes, irritability,
insomnia, high fever, and coma. In this study, to identify the components in PD, we first …
insomnia, high fever, and coma. In this study, to identify the components in PD, we first …
Living with a giant, flowering parasite: metabolic differences between Tetrastigma loheri Gagnep. (Vitaceae) shoots uninfected and infected with Rafflesia …
J Molina, D Nikolic, JR Jeevarathanam, R Abzalimov… - Planta, 2022 - Springer
Abstract Main conclusion Metabolites in Rafflesia-infected and non-infected Tetrastigma
were compared which may have applications in Rafflesia propagation. Benzylisoquinoline …
were compared which may have applications in Rafflesia propagation. Benzylisoquinoline …
[HTML][HTML] Exploring the effective components and potential mechanisms of Zukamu granules against acute upper respiratory tract infections by UHPLC-Q-Exactive …
K Li, Q Yao, M Zhang, Q Li, L Guo, J Li, J Yang… - Arabian Journal of …, 2023 - Elsevier
Acute upper respiratory tract infections (AURTIs) are common diseases of respiratory
system, which are caused by adenoviruses and generate the mix of severe clinical …
system, which are caused by adenoviruses and generate the mix of severe clinical …
Comprehensive characterization of multiple components of Ziziphus jujuba Mill using UHPLC‐Q‐Exactive Orbitrap Mass Spectrometers
S Qin, F Yan, SE, P Xiong, S Tang, K Yu… - Food Science & …, 2022 - Wiley Online Library
Ziziphus jujuba Mill is the dried ripe fruit of the Rhamnaceae family; it is widely distributed in
Shandong, Henan, Liaoning, and other places in China. In folk medicine, it was used to …
Shandong, Henan, Liaoning, and other places in China. In folk medicine, it was used to …
[HTML][HTML] Anti-hyperglycemic potential and chemical constituents of Aristolochia triangularis Cham. leaves− A medicinal species native to Brazilian forests
FHS de Araújo, CR Nogueira, VDK Trichez… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Aristolochia triangularis Cham. has been used in
Brazilian traditional medicine for various therapeutic purposes, including as a leaf-based …
Brazilian traditional medicine for various therapeutic purposes, including as a leaf-based …
Strong feedback inhibition of key enzymes in the morphine biosynthetic pathway from opium poppy detectable in engineered yeast
N Ozber, L Yu, JM Hagel, PJ Facchini - ACS Chemical Biology, 2023 - ACS Publications
Systematic screening of morphine pathway intermediates in engineered yeast revealed key
biosynthetic enzymes displaying potent feedback inhibition: 3′-hydroxy-N …
biosynthetic enzymes displaying potent feedback inhibition: 3′-hydroxy-N …