Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway

X Yang, S Gao, L Guo, B Wang, Y Jia, J Zhou… - Nature …, 2021 - nature.com
For millions of years, plants evolve plenty of structurally diverse secondary metabolites (SM)
to support their sessile lifestyles through continuous biochemical pathway innovation. While …

Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation

N Ozber, SC Carr, JS Morris, S Liang… - Nature …, 2022 - nature.com
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …

[HTML][HTML] Interpol Review of Drug Analysis 2019-2022

D Love, NS Jones - Forensic Science International: Synergy, 2023 - ncbi.nlm.nih.gov
Improved methods of analysis, ie, faster, more discriminatory, more sensitive, less costly,
etc., are needed for all abused substances. Additionally, standard analytical data are …

Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)

IM Menéndez-Perdomo, PJ Facchini - Scientific Reports, 2023 - nature.com
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized
metabolites found mainly in members of the order Ranunculales, including opium poppy …

[HTML][HTML] Phytochemical analysis and in vitro and in vivo antioxidant properties of Plagiorhegma dubia Maxim as a medicinal crop for diabetes treatment

H Sun, M Chen, X He, Y Sun, J Feng, X Guo, L Li… - Arabian Journal of …, 2023 - Elsevier
In traditional medicine, Plagiorhegma dubia Maxim (PD) is used to treat diabetes, irritability,
insomnia, high fever, and coma. In this study, to identify the components in PD, we first …

Living with a giant, flowering parasite: metabolic differences between Tetrastigma loheri Gagnep. (Vitaceae) shoots uninfected and infected with Rafflesia …

J Molina, D Nikolic, JR Jeevarathanam, R Abzalimov… - Planta, 2022 - Springer
Abstract Main conclusion Metabolites in Rafflesia-infected and non-infected Tetrastigma
were compared which may have applications in Rafflesia propagation. Benzylisoquinoline …

[HTML][HTML] Exploring the effective components and potential mechanisms of Zukamu granules against acute upper respiratory tract infections by UHPLC-Q-Exactive …

K Li, Q Yao, M Zhang, Q Li, L Guo, J Li, J Yang… - Arabian Journal of …, 2023 - Elsevier
Acute upper respiratory tract infections (AURTIs) are common diseases of respiratory
system, which are caused by adenoviruses and generate the mix of severe clinical …

Comprehensive characterization of multiple components of Ziziphus jujuba Mill using UHPLC‐Q‐Exactive Orbitrap Mass Spectrometers

S Qin, F Yan, SE, P Xiong, S Tang, K Yu… - Food Science & …, 2022 - Wiley Online Library
Ziziphus jujuba Mill is the dried ripe fruit of the Rhamnaceae family; it is widely distributed in
Shandong, Henan, Liaoning, and other places in China. In folk medicine, it was used to …

[HTML][HTML] Anti-hyperglycemic potential and chemical constituents of Aristolochia triangularis Cham. leaves− A medicinal species native to Brazilian forests

FHS de Araújo, CR Nogueira, VDK Trichez… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Aristolochia triangularis Cham. has been used in
Brazilian traditional medicine for various therapeutic purposes, including as a leaf-based …

Strong feedback inhibition of key enzymes in the morphine biosynthetic pathway from opium poppy detectable in engineered yeast

N Ozber, L Yu, JM Hagel, PJ Facchini - ACS Chemical Biology, 2023 - ACS Publications
Systematic screening of morphine pathway intermediates in engineered yeast revealed key
biosynthetic enzymes displaying potent feedback inhibition: 3′-hydroxy-N …