Regulation of chlamydial colonization by IFNγ delivered via distinct cells

H Winner, A Friesenhahn, Y Wang, N Stanbury… - Trends in …, 2023 - cell.com
The mouse-adapted pathogen Chlamydia muridarum (CM) induces pathology in the mouse
genital tract but fails to do so in the gastrointestinal tract. CM is cleared from both the genital …

Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization

G Zhong - Trends in microbiology, 2021 - cell.com
Chlamydia trachomatis (CT) is frequently detected in the human gastrointestinal (GI) tract
despite its leading role in sexually transmitted bacterial infections in the genital tract …

[HTML][HTML] Lactobacillus Modulates Chlamydia Infectivity and Genital Tract Pathology in vitro and in vivo

H Chen, S Min, L Wang, L Zhao, F Luo, W Lei… - Frontiers in …, 2022 - frontiersin.org
Since we previously reported that women infected with chlamydia had a significant overall
reduction in Lactobacillus in the vagina microbiota as compared to those uninfected …

IL-23 receptor signaling licenses group 3-like innate lymphoid cells to restrict a live-attenuated oral Chlamydia vaccine in the gut

Y He, Y Wang, R He, AM Abdelsalam… - Infection and …, 2023 - Am Soc Microbiol
An IFNγ-susceptible mutant of Chlamydia muridarum is attenuated in pathogenicity in the
genital tract and was recently licensed as an intr acellular O ral vaccine v ector or intrOv …

Adoptive transfer of group 3-like innate lymphoid cells restores mouse colon resistance to colonization of a gamma interferon-susceptible Chlamydia muridarum …

Y He, H Xu, C Song, JJ Koprivsek… - Infection and …, 2021 - Am Soc Microbiol
The obligate intracellular bacterium Chlamydia muridarum can colonize the mouse colon for
a long period, but a gamma interferon (IFN-γ)-susceptible mutant clone fails to do so …

Genomic analysis of MSM rectal Chlamydia trachomatis isolates identifies predicted tissue-tropic lineages generated by intraspecies lateral gene transfer-mediated …

RJ Suchland, SJ Carrell, SA Ramsey… - Infection and …, 2022 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium that causes serious diseases in
humans. Rectal infection and disease caused by this pathogen are important yet …

Chlamydia deficient in plasmid-encoded glycoprotein 3 (pGP3) as an attenuated live oral vaccine

Z Zhou, Q Tian, L Wang, G Zhong - Infection and immunity, 2022 - Am Soc Microbiol
Despite the extensive efforts, there is still a lack of a licensed vaccine against Chlamydia
trachomatis in humans. The mouse genital tract infection with Chlamydia muridarum has …

Regulation of chlamydial spreading from the small intestine to the large intestine by IL-22-producing CD4+ T cells

Y Xu, Y Wang, H Winner, H Yang, R He… - Infection and …, 2024 - Am Soc Microbiol
Following an oral inoculation, Chlamydia muridarum descends to the mouse large intestine
for long-lasting colonization. However, a mutant C. muridarum that lacks the plasmid …

Regulation of Chlamydia spreading from the small intestine to the large intestine via an immunological barrier

C He, Y Xu, Z Huo, J Wang, T Jia… - Immunology and Cell …, 2021 - Wiley Online Library
The obligate intracellular bacterium Chlamydia is a genital tract pathogen that can also
colonize the gastrointestinal tract for long periods. The long‐lasting colonization is …

Gastrointestinal Chlamydia-Induced CD8+ T Cells Promote Chlamydial Pathogenicity in the Female Upper Genital Tract

Q Tian, Z Zhou, L Wang, X Sun… - Infection and …, 2021 - Am Soc Microbiol
Chlamydia is known to both ascend to the upper genital tract and spread to the
gastrointestinal tract following intravaginal inoculation. Gastrointestinal Chlamydia was …