E-cadherin is the core component of epithelial adherens junctions, essential for tissue
development, differentiation, and maintenance. It is also fundamental for tissue barrier …

The intestinal epithelium acts as a key defensive barrier that protects internal organs from
the detrimental gut environment. The homeostasis of the gut epithelium may be altered by …

Renal ion channel transport and electrolyte disturbances play an important role in the
process of functional impairment and fibrosis in the kidney. It is well known that there are …

Liver X receptors (LXRα and LXRβ) are oxysterol-activated nuclear receptors that play key
roles in cholesterol homeostasis, the central nervous system, and the immune system. We …

Increasing evidence point out the important roles of ion channels in the physiopathology of
cancers, so that these proteins are now considered as potential new therapeutic targets and …

The incidence of gastrointestinal (GI) mucosal diseases, including various types of gastritis,
ulcers, inflammatory bowel disease and GI cancer, is increasing. Therefore, it is necessary to …

Isalo scorpion cytotoxic peptide (IsCT) is an α-helical antimicrobial peptide with antibacterial
and immunomodulatory activities. This research was performed to examine the link between …

Background Alginate oligosaccharide (AOS) has been reported to exert a crucial role in
maintaining the intestinal mucosal barrier (IMB) function. The current study aimed at …

Over the last two decades, the understanding of how dysregulated ion channels and
transporters are involved in carcinogenesis and tumor growth and progression, including …

Abstract Chloride channel-5 (ClC-5), an important branch of the ClC family, is involved in the
regulation of the proliferation and cell-fate of a variety of cells, including tumor cells …