Since its introduction more than twenty years ago, intraportal allogeneic cadaveric islet
transplantation has been shown to be a promising therapy for patients with Type I Diabetes …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

Background: The lack of an international islet transplantation registry has prevented full
visibility of worldwide islet transplantation activity. Methods: A global online survey was …

Pancreatic β-cells are responsible for maintaining glucose homeostasis. Therefore, their
dysregulation leads to diabetes. Pancreas or islet transplants can be used to treat diabetes …

Diabetes is a severe chronic disease worldwide. In various types of diabetes, the pancreatic
beta cells fail to secrete sufficient insulin, at some point, to regulate blood glucose levels …

Human allogeneic pancreatic islet transplantation is a life-changing treatment for patients
with severe Type 1 Diabetes (T1D) who suffer from hypoglycemia unawareness and high …

The discovery of insulin a century ago changed the lives of millions of individuals suffering
from diabetes, paving the way for long-term survival. While the availability of recombinant …

Background Porcine islet xenotransplantation is a promising treatment for type 1 diabetes as
an alternative to human pancreatic islet transplantation and long‐term insulin therapy …

Endocrine pancreas regulates glucose homeostasis and prevents diabetes. Type-1 diabetes
is characterized by destruction of the insulin secreting β-cells within the endocrine …

Abstract Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-
producing beta cells in the pancreas. Consequently, T1D patients produce little to no insulin …