Alzheimer's disease (AD) is the most common cause of dementia. Epidemiological studies
show the association between AD and type 2 diabetes (T2DM), although the mechanisms …

(1) Background: studies on the long-term dynamic changes in fat depot metabolism in
response to a high-fat diet (HFD) on hepatic lipid deposition and insulin resistance are …

Background Scientific evidence highlights the influence of biological sex on the relationship
between stress and metabolic dysfunctions. However, there is limited understanding of how …

Red rice bran extract (RRBE) has been reported to have the potential for in vitro metabolic
modulation and anti-inflammatory properties. However, little is known about the molecular …

Obesity is a significant health concern that often leads to metabolic dysfunction and chronic
diseases. This study introduces a novel approach to combat obesity using orally ingested …

Insulin resistance is associated with many pathological conditions, and an in-depth
understanding of the mechanisms involved is necessary to improve insulin sensitivity. Here …

Aims We evaluated the role of intergenerational paternal exercise on fibrosis, inflammatory
profile, and redox status in the adipose tissue of male rat offspring fed with high-fat diet …

Stimulation of hepatic sympathetic nerves increases glucose production and glycogenolysis.
Activity of pre-sympathetic neurons in the paraventricular nucleus (PVN) of the …

Introduction The enhanced β-cell senescence that accompanies insulin resistance and
aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 …

Obesity and aging promote chronic low-grade systemic inflammation. The aim of the study
was to analyze the effects of long-term physical exercise and/or omega-3 fatty acid …